History & Culture
Since the 10th century the name Limon appears in many documents, often transformed into Limonum, Limono and Limone. According to some, the name derives from limen = border or from lima = river. However, these are not derivatives of the fruit 'lemon', but, according to the most recent studies in toponymy, "rather reflections of an ancient voice of Celtic origin limo, lemos = 'elm'"; hence Limone = "place characterized by the presence of elms". The name of the town has been Limone San Giovanni since 1863; in 1904 it took on its current name of Limone sul Garda.
The first evidence of human settlements on the shores of Benàco (the ancient name for Lake Garda) dates to Neolithic times. The southern shores and surrounding moraine hills are the densest area of pile-dwelling sites in Italy. More than 40 settlements are known to exist in this area; today, together with the pile-dwelling villages of Fiavé (3800-3600 BC) and Ledro (2200-1350 BC) they are part of the UNESCO World Heritage List.
The Legend of Limone
Legend has it that the love of the god Benaco and the nymph Fillide gave birth to twins, Grineo and Limone. In their father's mind, the first should have devoted himself to fishing, the second to agriculture, but the two, since their adolescence, preferred hunting on the slopes of Mount Baldo, where Limone was attacked and killed by a wild boar. In despair, Fillide pleaded with her husband to bring her son back to life: she gave him an infusion prepared with mysterious celestial flowers and the miracle was accomplished. Promptly obeying his father's wishes, Limone settled down in front of Baldo, in a gentle inlet sheltered from the winds, and cultivated the fruit that took his name.
Long-life elixir in Limone
The story of the discovery began in 1979 in Milan, when a railway employee from Limone was admitted to hospital. The results of the tests he underwent stunned the team of doctors led by Prof. Cesare Sirtori. The patient's cholesterol and triglycerides were very high, but there was no significant damage to the arteries or heart. The doctors, in disbelief, decided to investigate further and found an anomalous protein in the blood of the patient, his father and daughter, which the researchers named A-1 Milano.
The most important thing is that the protein present in the blood of these people from Limone behaves in an anomalous but beneficial way, becoming an extremely effective weapon against atherosclerosis and heart attacks. As a result of this protein, fats are 'swept at great speed' from the arteries and transported to the liver where they are eliminated.
The researchers were curious as to why this genetic mutation only occurred in Lemon and wanted to find out how hereditary and environmental factors might have influenced it. The studies and research continued with increasing dedication, and all the inhabitants of the village had their blood taken. The result is surprising: a considerable number of residents carries the gene. The family tree of the carriers was investigated, and, thanks to old registers, it was established that all the carriers descended from a single couple: Cristoforo Pomaroli and Rosa Giovanelli, who married in Limone on 14 November 1644.
In the years following the discovery, research moved to major laboratories around the world, particularly in northern Europe and the United States, but it was only possible thanks to the invaluable collaboration of the inhabitants of Limone who submitted to the research. It was thus possible to synthesize A1 Milano by transferring the ability to reproduce the protein into bacteria. In November 2003, news arrived that a group of researchers from the Cleveland Clinic Foundation, led by Steven Nissen, had reproduced the protein in an experimental drug.
The drug was administered to forty-seven people suffering from severe atherosclerosis, and in just six weeks, led to the surprising result of an average reduction in plaque of 4.2%. In May 2004, Limone hosted an important international scientific conference, where leading American experts discussed the longevity of the country's inhabitants. The good news continued when Prof. Sirtori's medical team returned to the village to carry out tests on the children of the gene carriers and identified the precious protein in the blood of eight children. This continues the incredible story of the elixir of life, which has been passed on from generation to generation, from the first pair of carriers to the present day.
In October 2012, the international scientific congress 'Present status of HDL Therapy' was held in Limone. It was announced that innovative drugs derived from the Limone apolipoprotein would be launched on the market within a few years.